| Affiliate | Manager | Pitching Coach | Hitting Coach |
| Rochester | Matthew LeCroy | Michael Tejera | Brian Daubach |
| Harrisburg | Tripp Keister | Sam Narron | Brian Rupp |
| Wilmington | Tommy Shields | Justin Lord | Luis Ordaz |
| Fredericksburg | Mario Lisson | Pat Rice | Jorge Mejia |
| GCL | Jake Lowery | Franklin Bravo Larry Pardo |
Mark Harris |
| DSL | Sandy Martinez | Edwin Hurtado | Freddy Guzman |
Bold = New to the organization
Italics = New assignment
Perhaps the most notable is the return of Matthew LeCroy to the dugout, so those AAA and AAAA guys best run out those popups and ground balls!
Count Jake Lowery as the latest longtime backup catcher to become manager. If the name’s familiar, it’s because he spent the last four years of his nine-year career with Washington, mostly at Harrisburg. Lowery was drafted out of JMU by Cleveland in the 4th Rd. of the 2011 Draft.
Longtime High-A manager Tripp Keister moves up to AA while Tommy Shields takes his place to manage the new High-A affiliate in Wilmington. Shields still holds the title of co-field coordinator along with Jeff Garber, who is also the XST field manager.
The rest of the pitching and hitting coaches are largely the same as named for 2020 in December 2019, with Franklin Bravo and Mark Harris landing in Florida with the elimination of the SS-A level.